// Workers AI · dad joke modeWhy did CREB/ATF bZIP go to therapy? It had a binding issue.

CREBZF
Identifiers
Aliases	CREBZF, SMILE, ZF, CREB/ATF bZIP transcription factor
External IDs	OMIM: 606444; MGI: 2675296; HomoloGene: 10926; GeneCards: CREBZF; OMA:CREBZF - orthologs
Gene location (Human) Chr. Chromosome 11 (human) Band 11q14.1 Start 85,659,708 bp End 85,682,908 bp
Gene location (Mouse) Chr. Chromosome 7 (mouse) Band 7|7 E1 Start 90,091,937 bp End 90,097,202 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in sural nerve left ovary right ovary body of uterus right hemisphere of cerebellum cardia ventricular zone right lung canal of the cervix left lobe of thyroid gland Top expressed in neural layer of retina ventricular zone genital tubercle cerebellar cortex thymus tail of embryo spermatocyte lobe of cerebellum ganglionic eminence superior frontal gyrus More reference expression data BioGPS n/a
Gene ontology Molecular function DNA-binding transcription factor activity DNA binding protein binding identical protein binding DNA-binding transcription factor activity, RNA polymerase II-specific Cellular component nucleus mitochondrion Biological process response to virus negative regulation of gene expression, epigenetic negative regulation of transcription, DNA-templated regulation of transcription, DNA-templated regulation of DNA-binding transcription factor activity transcription, DNA-templated regulation of transcription by RNA polymerase II Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 58487 233490 Ensembl ENSG00000137504 ENSMUSG00000051451 UniProt Q9NS37 Q91ZR3 RefSeq (mRNA) NM_001039618 NM_021212 NM_145151 RefSeq (protein) NP_001034707 NP_660133 Location (UCSC) Chr 11: 85.66 – 85.68 Mb Chr 7: 90.09 – 90.1 Mb PubMed search
Wikidata
View/Edit Human View/Edit Mouse

CREB/ATF bZIP transcription factor is a protein that in humans is encoded by the CREBZF gene.

Further reading

• Misra V, Rapin N, Akhova O, Bainbridge M, Korchinski P (2005). "Zhangfei is a potent and specific inhibitor of the host cell factor-binding transcription factor Luman". J. Biol. Chem. 280 (15): 15257–66. doi:10.1074/jbc.M500728200. PMID 15705566.
• Akhova O, Bainbridge M, Misra V (2005). "The neuronal host cell factor-binding protein Zhangfei inhibits herpes simplex virus replication". J. Virol. 79 (23): 14708–18. doi:10.1128/JVI.79.23.14708-14718.2005. PMC 1287584. PMID 16282471.
• Hogan MR, Cockram GP, Lu R (2006). "Cooperative interaction of Zhangfei and ATF4 in transactivation of the cyclic AMP response element". FEBS Lett. 580 (1): 58–62. Bibcode:2006FEBSL.580...58H. doi:10.1016/j.febslet.2005.11.046. PMID 16343488. S2CID 34571628.
• Xie YB, Lee OH, Nedumaran B, Seong HA, Lee KM, Ha H, Lee IK, Yun Y, Choi HS (2008). "SMILE, a new orphan nuclear receptor SHP-interacting protein, regulates SHP-repressed estrogen receptor transactivation". Biochem. J. 416 (3): 463–73. doi:10.1042/BJ20080782. PMID 18657049.
• Valderrama X, Rapin N, Verge VM, Misra V (2009). "Zhangfei induces the expression of the nerve growth factor receptor, trkA, in medulloblastoma cells and causes their differentiation or apoptosis". J. Neurooncol. 91 (1): 7–17. doi:10.1007/s11060-008-9682-6. PMID 18719857. S2CID 25560950.
• Valderrama X, Rapin N, Verge VM, Misra V (2009). "Zhangfei induces the expression of the nerve growth factor receptor, trkA, in medulloblastoma cells and causes their differentiation or apoptosis". J. Neurooncol. 91 (1): 7–17. doi:10.1007/s11060-008-9682-6. PMID 18719857. S2CID 25560950.
• Valderrama X, Rapin N, Misra V (2008). "Zhangfei, a novel regulator of the human nerve growth factor receptor, trkA". J. Neurovirol. 14 (5): 425–36. doi:10.1080/13550280802275904. PMID 19016376. S2CID 20896925.
• Xie YB, Park JH, Kim DK, Hwang JH, Oh S, Park SB, Shong M, Lee IK, Choi HS (2009). "Transcriptional corepressor SMILE recruits SIRT1 to inhibit nuclear receptor estrogen receptor-related receptor gamma transactivation". J. Biol. Chem. 284 (42): 28762–74. doi:10.1074/jbc.M109.034165. PMC 2781422. PMID 19690166.
• Racapé M, Duong Van Huyen JP, Danger R, Giral M, Bleicher F, Foucher Y, Pallier A, Pilet P, Tafelmeyer P, Ashton-Chess J, Dugast E, Pettré S, Charreau B, Soulillou JP, Brouard S (2011). "The involvement of SMILE/TMTC3 in endoplasmic reticulum stress response". PLOS ONE. 6 (5) e19321. Bibcode:2011PLoSO...619321R. doi:10.1371/journal.pone.0019321. PMC 3095597. PMID 21603654.