COP1

Not to be confused with COPI.

CARD16
Identifiers
Aliases	CARD16, COP, COP1, PSEUDO-ICE, caspase recruitment domain family member 16, LLID-114769
External IDs	OMIM: 615680; HomoloGene: 133086; GeneCards: CARD16; OMA:CARD16 - orthologs
Gene location (Human) Chr. Chromosome 11 (human) Band 11q22.3 Start 105,041,326 bp End 105,101,431 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in monocyte granulocyte stromal cell of endometrium spleen appendix germinal epithelium bone marrow bone marrow cell mucosa of transverse colon superficial temporal artery n/a More reference expression data BioGPS n/a
Gene ontology Molecular function peptidase inhibitor activity protein binding kinase binding identical protein binding caspase binding CARD domain binding cysteine-type endopeptidase inhibitor activity cysteine-type endopeptidase activity Cellular component protease inhibitor complex protein-containing complex Biological process regulation of apoptotic process negative regulation of peptidase activity negative regulation of lipopolysaccharide-mediated signaling pathway negative regulation of protein binding positive regulation of NF-kappaB transcription factor activity inhibition of cysteine-type endopeptidase activity negative regulation of tumor necrosis factor-mediated signaling pathway negative regulation of cysteine-type endopeptidase activity involved in apoptotic process cellular response to hypoxia cellular response to UV-C positive regulation of I-kappaB kinase/NF-kappaB signaling cellular response to lipopolysaccharide proteolysis Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 114769 n/a Ensembl ENSG00000204397 n/a UniProt Q5EG05 n/a RefSeq (mRNA) NM_001017534 NM_052889 NM_001394580 n/a RefSeq (protein) NP_001017534 NP_443121 n/a Location (UCSC) Chr 11: 105.04 – 105.1 Mb n/a PubMed search n/a
Wikidata
View/Edit Human

Fagol Caspase recruitment domain-containing protein 16 is an enzyme that in humans is encoded by the CARD16 gene. It functions as a caspase inhibitor, in particular inhibiting the activation of caspase 1 and caspase 4.

External links

• Human CARD16 genome location and CARD16 gene details page in the UCSC Genome Browser.

Further reading

• Wang X, Narayanan M, Bruey JM, et al. (2006). "Protective role of Cop in Rip2/caspase-1/caspase-4-mediated HeLa cell death". Biochim. Biophys. Acta. 1762 (8): 742–54. doi:10.1016/j.bbadis.2006.06.015. PMID 16920334.
• Wang X, Wang H, Figueroa BE, et al. (2006). "Dysregulation of receptor interacting protein-2 and caspase recruitment domain only protein mediates aberrant caspase-1 activation in Huntington's disease". J. Neurosci. 25 (50): 11645–54. doi:10.1523/JNEUROSCI.4181-05.2005. PMC 6726023. PMID 16354923.
• Lamkanfi M, Denecker G, Kalai M, et al. (2005). "INCA, a novel human caspase recruitment domain protein that inhibits interleukin-1beta generation". J. Biol. Chem. 279 (50): 51729–38. doi:10.1074/jbc.M407891200. PMID 15383541.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Razmara M, Srinivasula SM, Wang L, et al. (2002). "CARD-8 protein, a new CARD family member that regulates caspase-1 activation and apoptosis". J. Biol. Chem. 277 (16): 13952–8. doi:10.1074/jbc.M107811200. PMID 11821383.