// Workers AI · dad joke modeWhat did VSX2 say to VSX? "You versus me, times two.

VSX2
Identifiers
Aliases	VSX2, CHX10, HOX10, MCOP2, MCOPCB3, RET1, visual system homeobox 2
External IDs	OMIM: 142993; MGI: 88401; HomoloGene: 7266; GeneCards: VSX2; OMA:VSX2 - orthologs
Gene location (Human)
Chr.	Chromosome 14 (human)
End	74,262,738 bp
Gene location (Mouse)
Chr.	Chromosome 12 (mouse)
End	84,642,231 bp
RNA expression pattern
	Top expressed in
	testicle; ; gonad; ; lymph node; ; C1 segment; ; nucleus of brain; ; substantia nigra; ; subcutaneous adipose tissue; ; hypothalamus; ; anterior pituitary;
	Top expressed in
	neural layer of retina; ; lens; ; ciliary body; ; corneal stroma; ; inner nuclear layer; ; iris; ; lumbar subsegment of spinal cord; ; epithelium of lens; ; gastrula; ; central gray substance of midbrain;
	More reference expression data
	n/a
Gene ontology
Molecular function	sequence-specific DNA binding; DNA binding; DNA-binding transcription factor activity, RNA polymerase II-specific;
Cellular component	nucleus;
Biological process	multicellular organism development; regulation of transcription, DNA-templated; transcription, DNA-templated; response to stimulus; visual perception; regulation of transcription by RNA polymerase II;
	Sources:Amigo / QuickGO
Orthologs
	338917
	12677
	ENSG00000119614
	ENSMUSG00000021239
	P58304
	Q61412
	NM_182894
	NM_001301427; NM_007701
	NP_878314
	NP_001288356; NP_031727
	Wikidata
View/Edit Human	View/Edit Mouse

Visual system homeobox 2 is a protein that in humans is encoded by the VSX2 gene.^[5]^[6]

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000119614 – Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000021239 – Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ McAlpine PJ, Shows TB (July 1990). "Nomenclature for human homeobox genes". Genomics. 7 (3): 460. doi:10.1016/0888-7543(90)90186-X. PMID 1973146.
↑ "Entrez Gene: CHX10 ceh-10 homeodomain containing homolog (C. elegans)".

Sanger Center, Washington University Genome Sequencing Center (November 1998). "Toward a complete human genome sequence". Genome Research. 8 (11): 1097–1108. doi:10.1101/gr.8.11.1097. PMID 9847074.
Ferda Percin E, Ploder LA, Yu JJ, Arici K, Horsford DJ, Rutherford A, et al. (August 2000). "Human microphthalmia associated with mutations in the retinal homeobox gene CHX10". Nature Genetics. 25 (4): 397–401. doi:10.1038/78071. PMID 10932181. S2CID 9508022.
Mikkola I, Bruun JA, Holm T, Johansen T (February 2001). "Superactivation of Pax6-mediated transactivation from paired domain-binding sites by dna-independent recruitment of different homeodomain proteins". The Journal of Biological Chemistry. 276 (6): 4109–4118. doi:10.1074/jbc.M008882200. PMID 11069920.
Bar-Yosef U, Abuelaish I, Harel T, Hendler N, Ofir R, Birk OS (September 2004). "CHX10 mutations cause non-syndromic microphthalmia/ anophthalmia in Arab and Jewish kindreds". Human Genetics. 115 (4): 302–309. doi:10.1007/s00439-004-1154-2. PMID 15257456. S2CID 28981190.
Dorval KM, Bobechko BP, Ahmad KF, Bremner R (March 2005). "Transcriptional activity of the paired-like homeodomain proteins CHX10 and VSX1". The Journal of Biological Chemistry. 280 (11): 10100–10108. doi:10.1074/jbc.M412676200. PMID 15647262.
Kuiper H, Spötter A, Williams JL, Distl O, Drögemüller C (2005). "Physical mapping of CHX10, ALDH6A1, and ABCD4 on bovine chromosome 10q34". Cytogenetic and Genome Research. 109 (4): 533. doi:10.1159/000084217. PMID 15909363.
Dorval KM, Bobechko BP, Fujieda H, Chen S, Zack DJ, Bremner R (January 2006). "CHX10 targets a subset of photoreceptor genes". The Journal of Biological Chemistry. 281 (2): 744–751. doi:10.1074/jbc.M509470200. PMID 16236706.
Faiyaz-Ul-Haque M, Zaidi SH, Al-Mureikhi MS, Peltekova I, Tsui LC, Teebi AS (August 2007). "Mutations in the CHX10 gene in non-syndromic microphthalmia/anophthalmia patients from Qatar". Clinical Genetics. 72 (2): 164–166. doi:10.1111/j.1399-0004.2007.00846.x. PMID 17661825. S2CID 6218901.

This article on a gene on human chromosome 14 is a stub. You can help Wikipedia by adding missing information.

[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000119614 – Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000021239 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid1973146-5] McAlpine PJ, Shows TB (July 1990). "Nomenclature for human homeobox genes". Genomics. 7 (3): 460. doi:10.1016/0888-7543(90)90186-X. PMID 1973146.

[entrez-6] "Entrez Gene: CHX10 ceh-10 homeodomain containing homolog (C. elegans)".

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// Workers AI · dad joke modeWhat did VSX2 say to VSX? "You versus me, times two.

References

Further reading