Chromatin target of PRMT1

CHTOP
Identifiers
Aliases	CHTOP, C1orf77, FL-SRAG, FOP, SRAG, SRAG-3, SRAG-5, pp7704, chromatin target of PRMT1, C10orf77
External IDs	OMIM: 614206; MGI: 1913761; HomoloGene: 134556; GeneCards: CHTOP; OMA:CHTOP - orthologs
Gene location (Human) Chr. Chromosome 1 (human) Band 1q21.3 Start 153,633,982 bp End 153,646,306 bp
Gene location (Mouse) Chr. Chromosome 3 (mouse) Band 3|3 F1 Start 90,406,263 bp End 90,416,805 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in tendon of biceps brachii ventricular zone ganglionic eminence body of pancreas right lobe of thyroid gland granulocyte left lobe of thyroid gland canal of the cervix left ovary right ovary Top expressed in saccule otic placode otic vesicle Gonadal ridge hand maxillary prominence mandibular prominence medial ganglionic eminence somite endocardial cushion More reference expression data BioGPS n/a
Gene ontology Molecular function methyl-CpG binding protein binding RNA binding Cellular component nuclear speck nucleolus transcription export complex nucleus nucleoplasm cytoplasmic ribonucleoprotein granule Biological process mRNA transport regulation of transcription, DNA-templated positive regulation of ATP-dependent activity positive regulation of helicase activity positive regulation of histone methylation transcription, DNA-templated positive regulation of cell population proliferation RNA export from nucleus termination of RNA polymerase II transcription mRNA export from nucleus mRNA 3'-end processing transport Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 26097 66511 Ensembl ENSG00000160679 ENSMUSG00000001017 UniProt Q9Y3Y2 Q9CY57 RefSeq (mRNA) NM_001206612 NM_001244664 NM_015607 NM_001317077 NM_001293776 NM_001293777 NM_001293778 NM_001293779 NM_001293780 NM_001293781 NM_001293782 NM_023215 RefSeq (protein) NP_001193541 NP_001231593 NP_001304006 NP_056422 NP_001280705 NP_001280706 NP_001280707 NP_001280708 NP_001280709 NP_001280710 NP_001280711 NP_075704 Location (UCSC) Chr 1: 153.63 – 153.65 Mb Chr 3: 90.41 – 90.42 Mb PubMed search
Wikidata
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Chromatin target of PRMT1 is a protein that in humans is encoded by the CHTOP gene.

Function

This gene encodes a small nuclear protein that is characterized by an arginine and glycine rich region. The encoded protein may be involved in cell cycle progression. This protein interacts with protein arginine methyltransferases and plays a role in the activation of estradiol-dependent transcription. Alternate splicing results in multiple transcript variants.

Further reading

• Zullo AJ, Michaud M, Zhang W, Grusby MJ (May 2009). "Identification of the small protein rich in arginine and glycine (SRAG): a newly identified nucleolar protein that can regulate cell proliferation". The Journal of Biological Chemistry. 284 (18): 12504–11. doi:10.1074/jbc.M809436200. PMC 2673316. PMID 19254951.
• Chang CT, Hautbergue GM, Walsh MJ, Viphakone N, van Dijk TB, Philipsen S, Wilson SA (February 2013). "Chtop is a component of the dynamic TREX mRNA export complex". The EMBO Journal. 32 (3): 473–86. doi:10.1038/emboj.2012.342. PMC 3567497. PMID 23299939.
• Teng IF, Wilson SA (2013). "Mapping interactions between mRNA export factors in living cells". PLOS ONE. 8 (6) e67676. Bibcode:2013PLoSO...867676T. doi:10.1371/journal.pone.0067676. PMC 3691119. PMID 23826332.
• van Dijk TB, Gillemans N, Stein C, Fanis P, Demmers J, van de Corput M, Essers J, Grosveld F, Bauer UM, Philipsen S (January 2010). "Friend of Prmt1, a novel chromatin target of protein arginine methyltransferases". Molecular and Cellular Biology. 30 (1): 260–72. doi:10.1128/MCB.00645-09. PMC 2798285. PMID 19858291.
• van Dijk TB, Gillemans N, Pourfarzad F, van Lom K, von Lindern M, Grosveld F, Philipsen S (November 2010). "Fetal globin expression is regulated by Friend of Prmt1". Blood. 116 (20): 4349–52. doi:10.1182/blood-2010-03-274399. PMC 2993632. PMID 20688955.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.