// Workers AI · dad joke modeWhat did Calpain small subunit 1 say? I'm cutting ties.

CAPNS1
Identifiers
Aliases	CAPNS1, 30K, CALPAIN4, CANP, CANPS, CAPN4, CDPS, CSS1, calpain small subunit 1, Calpain small subunit 1
External IDs	OMIM: 114170; MGI: 88266; GeneCards: CAPNS1
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1KFU, 1KFX, 4PHJ, 4PHK, 4PHM, 4WQ2, 4WQ3, 5D69
Gene location (Human) Chr. Chromosome 19 (human) Band 19q13.12 Start 36,139,953 bp End 36,150,353 bp
Gene location (Mouse) Chr. Chromosome 7 (mouse) Band 7 B1|7 17.31 cM Start 29,886,361 bp End 29,898,236 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in stromal cell of endometrium mucosa of ileum granulocyte prefrontal cortex right frontal lobe right uterine tube right lung upper lobe of left lung right lobe of thyroid gland left lobe of thyroid gland Top expressed in spermatid spermatocyte genital tubercle tail of embryo ankle granulocyte muscle of thigh corneal stroma dentate gyrus of hippocampal formation granule cell facial motor nucleus More reference expression data BioGPS n/a
Gene ontology Molecular function calcium ion binding protein binding calcium-dependent cysteine-type endopeptidase activity metal ion binding endopeptidase activity Cellular component cytoplasm extracellular exosome membrane cytosol plasma membrane Biological process extracellular matrix disassembly regulation of macroautophagy positive regulation of cell population proliferation proteolysis cornification Sources:Amigo / QuickGO
Orthologs Databases NCBI: entry; OMA: entry Species Human Mouse Entrez 826 12336 Ensembl ENSG00000126247 ENSMUSG00000001794 UniProt P04632 O88456 RefSeq (mRNA) NM_001003962 NM_001302632 NM_001302633 NM_001749 NM_009795 RefSeq (protein) NP_001003962 NP_001289561 NP_001289562 NP_001740 NP_033925 Location (UCSC) Chr 19: 36.14 – 36.15 Mb Chr 7: 29.89 – 29.9 Mb PubMed search
Wikidata
View/Edit Human View/Edit Mouse

Calpain small subunit 1 (CSS1) is a protein that in humans is encoded by the CAPNS1 gene.

Function

Calpains are a ubiquitous, well-conserved family of calcium-dependent, cysteine proteases. Calpain families have been implicated in neurodegenerative processes, as their activation can be triggered by calcium influx and oxidative stress. Calpain I and II are heterodimeric with distinct large subunits associated with common small subunits, all of which are encoded by different genes. The small regulatory subunit consists of an N-terminal domain, containing about 30% glycine residues and a C-terminal Ca-binding domain. Two transcript variants encoding the same protein have been identified for this gene.

Functions

Myotonic dystrophy

This gene encodes a small subunit common to both calpain I and II and is associated with myotonic dystrophy.

Biomarker

'Elevated expression of CAPNS1 has been found to be associated with progression of various cancers such as hepatocellular and renal carcinoma.

External links

• Human CAPNS1 genome location and CAPNS1 gene details page in the UCSC Genome Browser.

Further reading

• Suzuki K, Sorimachi H, Yoshizawa T, Kinbara K, Ishiura S (September 1995). "Calpain: novel family members, activation, and physiologic function". Biological Chemistry Hoppe-Seyler. 376 (9): 523–9. doi:10.1515/bchm3.1995.376.9.523. PMID 8561910.
• Tidball JG, Spencer MJ (January 2000). "Calpains and muscular dystrophies". The International Journal of Biochemistry & Cell Biology. 32 (1): 1–5. doi:10.1016/S1357-2725(99)00095-3. PMID 10661889.
• Huang Y, Wang KK (August 2001). "The calpain family and human disease". Trends in Molecular Medicine. 7 (8): 355–62. doi:10.1016/S1471-4914(01)02049-4. PMID 11516996.
• Reverter D, Sorimachi H, Bode W (August 2001). "The structure of calcium-free human m-calpain: implications for calcium activation and function". Trends in Cardiovascular Medicine. 11 (6): 222–9. doi:10.1016/S1050-1738(01)00112-8. PMID 11673052.
• Banik NL, DeVries GH, Neuberger T, Russell T, Chakrabarti AK, Hogan EL (July 1991). "Calcium-activated neutral proteinase (CANP; calpain) activity in Schwann cells: immunofluorescence localization and compartmentation of mu- and mCANP". Journal of Neuroscience Research. 29 (3): 346–54. doi:10.1002/jnr.490290310. PMID 1656060. S2CID 40120102.
• Ohno S, Minoshima S, Kudoh J, Fukuyama R, Shimizu Y, Ohmi-Imajoh S, Shimizu N, Suzuki K (1990). "Four genes for the calpain family locate on four distinct human chromosomes". Cytogenetics and Cell Genetics. 53 (4): 225–9. doi:10.1159/000132937. PMID 2209092.
• Andersson B, Wentland MA, Ricafrente JY, Liu W, Gibbs RA (April 1996). "A "double adaptor" method for improved shotgun library construction". Analytical Biochemistry. 236 (1): 107–13. doi:10.1006/abio.1996.0138. PMID 8619474.
• Zhang W, Lane RD, Mellgren RL (August 1996). "The major calpain isozymes are long-lived proteins. Design of an antisense strategy for calpain depletion in cultured cells". The Journal of Biological Chemistry. 271 (31): 18825–30. doi:10.1074/jbc.271.31.18825. PMID 8702541.
• Yu W, Andersson B, Worley KC, Muzny DM, Ding Y, Liu W, Ricafrente JY, Wentland MA, Lennon G, Gibbs RA (April 1997). "Large-scale concatenation cDNA sequencing". Genome Research. 7 (4): 353–8. doi:10.1101/gr.7.4.353. PMC 139146. PMID 9110174.
• Noguchi M, Sarin A, Aman MJ, Nakajima H, Shores EW, Henkart PA, Leonard WJ (October 1997). "Functional cleavage of the common cytokine receptor gamma chain (gammac) by calpain". Proceedings of the National Academy of Sciences of the United States of America. 94 (21): 11534–9. Bibcode:1997PNAS...9411534N. doi:10.1073/pnas.94.21.11534. PMC 23528. PMID 9326644.
• Strobl S, Fernandez-Catalan C, Braun M, Huber R, Masumoto H, Nakagawa K, Irie A, Sorimachi H, Bourenkow G, Bartunik H, Suzuki K, Bode W (January 2000). "The crystal structure of calcium-free human m-calpain suggests an electrostatic switch mechanism for activation by calcium". Proceedings of the National Academy of Sciences of the United States of America. 97 (2): 588–92. Bibcode:2000PNAS...97..588S. doi:10.1073/pnas.97.2.588. PMC 15374. PMID 10639123.
• Masumoto H, Nakagawa K, Irie S, Sorimachi H, Suzuki K, Bourenkov GP, Bartunik H, Fernandez-Catalan C, Bode W, Strobl S (January 2000). "Crystallization and preliminary X-ray analysis of recombinant full-length human m-calpain". Acta Crystallographica Section D. 56 (Pt 1): 73–5. Bibcode:2000AcCrD..56...73M. doi:10.1107/S0907444999013748. PMID 10666632.
• Dias Neto E, Correa RG, Verjovski-Almeida S, Briones MR, Nagai MA, da Silva W, Zago MA, Bordin S, Costa FF, Goldman GH, Carvalho AF, Matsukuma A, Baia GS, Simpson DH, Brunstein A, de Oliveira PS, Bucher P, Jongeneel CV, O'Hare MJ, Soares F, Brentani RR, Reis LF, de Souza SJ, Simpson AJ (March 2000). "Shotgun sequencing of the human transcriptome with ORF expressed sequence tags". Proceedings of the National Academy of Sciences of the United States of America. 97 (7): 3491–6. Bibcode:2000PNAS...97.3491D. doi:10.1073/pnas.97.7.3491. PMC 16267. PMID 10737800.
• Reverter D, Strobl S, Fernandez-Catalan C, Sorimachi H, Suzuki K, Bode W (May 2001). "Structural basis for possible calcium-induced activation mechanisms of calpains". Biological Chemistry. 382 (5): 753–66. doi:10.1515/BC.2001.091. PMID 11517928. S2CID 23221865.