Calcitonin gene-related peptide 2

CALCB
Identifiers
Aliases	CALCB, CALC2, CGRP-II, CGRP2, calcitonin related polypeptide beta
External IDs	OMIM: 114160; MGI: 2151253; GeneCards: CALCB
Gene location (Human)
Chr.	Chromosome 11 (human)
End	15,082,342 bp
Gene location (Mouse)
Chr.	Chromosome 7 (mouse)
End	114,235,592 bp
RNA expression pattern
	Top expressed in
	spinal ganglia; ; trigeminal ganglion; ; islet of Langerhans; ; gonad; ; testicle; ; hypothalamus; ; anterior pituitary; ; body of pancreas; ; muscle layer of sigmoid colon; ; retinal pigment epithelium;
	Top expressed in
	facial motor nucleus; ; motor neuron; ; lumbar spinal ganglion; ; anterior horn of spinal cord; ; lactiferous gland; ; trachea; ; trigeminal ganglion; ; embryo; ; embryo; ; vestibular membrane of cochlear duct;
	More reference expression data
	n/a
Gene ontology
Molecular function	neuropeptide hormone activity; hormone activity; calcitonin receptor binding;
Cellular component	extracellular region; extracellular space; intracellular anatomical structure;
Biological process	cellular calcium ion homeostasis; signal transduction; regulation of signaling receptor activity; G protein-coupled receptor signaling pathway; adenylate cyclase-activating G protein-coupled receptor signaling pathway; regulation of cytosolic calcium ion concentration;
	Sources:Amigo / QuickGO
Orthologs
Databases	NCBI: entry; OMA: entry
	797
	12310
	ENSG00000175868
	ENSMUSG00000030669
	P10092
	P70160; Q99JA0
	NM_000728
	NM_001033954; NM_007587; NM_001289444; NM_001305616
	NP_000719
NP_001029126; NP_001276373; NP_001292545; NP_031613; NP_001029126.1;
	NP_001276373.1
	Wikidata
View/Edit Human	View/Edit Mouse

Calcitonin gene-related peptide 2 (CGRP2), also called calcitonin related polypeptide beta, is a hormone that in humans is encoded by the CALCB gene (previously CALC2).^[5]^[6] Like the related hormone, calcitonin gene-related peptide 1 (CGRP1),^[7] this hormone induces vasodilation (relaxation of blood vessels) through the activation of the CGRP receptor.^[6]^[8] This form of calcitonin gene-related peptide is traditionally considered to be the primary form used in the enteric nervous system (nervous system in the gut).^[8] The gene that encodes CGRP1, CALCA, also encodes the blood-calcium-reducing hormone calcitonin, but despite its name, this protein is encoded by a distinct gene (CALCB).^[8]

Receptors

This hormone activates the CGRP receptor, which is a two protein (heterodimer) complex that is composed of RAMP1 and CALCRL.^[8]

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000175868 – Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000030669 – Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "CALCB calcitonin related polypeptide beta". Entrez Gene. NCBI. Retrieved 2026-09-10.
1 2 "Calcitonin gene-related peptide 2". uniprot.org. UniProt consortium. Retrieved 2026-09-20.
↑ "Calcitonin gene-related peptide 1". uniprot.org. UniProt consortium. Retrieved 2026-09-20.
1 2 3 4 Russell FA, King R, Smillie SJ, Kodji X, Brain SD (2014-10-01). "Calcitonin gene-related peptide: physiology and pathophysiology". Physiological reviews. doi:10.1152/physrev.00034.2013.

This article on a gene on human chromosome 11 is a stub. You can help Wikipedia by adding missing information.

[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000175868 – Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000030669 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez-5] "CALCB calcitonin related polypeptide beta". Entrez Gene. NCBI. Retrieved 2026-09-10.

[uniprot-6] 1 2 "Calcitonin gene-related peptide 2". uniprot.org. UniProt consortium. Retrieved 2026-09-20.

[UniprotCALCA-7] "Calcitonin gene-related peptide 1". uniprot.org. UniProt consortium. Retrieved 2026-09-20.

[Russel2014-8] 1 2 3 4 Russell FA, King R, Smillie SJ, Kodji X, Brain SD (2014-10-01). "Calcitonin gene-related peptide: physiology and pathophysiology". Physiological reviews. doi:10.1152/physrev.00034.2013.

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Calcitonin gene-related peptide 2

Receptors

References