// Workers AI · dad joke modeWhat did CSN2 say to its date? "You're a formula for love, CSN2 me".

CSN2
Identifiers
Aliases	CSN2, CASB, casein beta, PDC213
External IDs	OMIM: 115460; MGI: 88541; GeneCards: CSN2
Gene location (Human)
Chr.	Chromosome 4 (human)
End	69,965,728 bp
Gene location (Mouse)
Chr.	Chromosome 5 (mouse)
End	87,847,489 bp
RNA expression pattern
	Top expressed in
	testicle; ; tonsil; ; salivary gland; ; minor salivary glands; ; olfactory zone of nasal mucosa; ; islet of Langerhans; ; smooth muscle tissue; ; placenta; ; urinary bladder; ; skeletal muscle;
	Top expressed in
	lactiferous gland; ; parotid gland; ; muscle of thigh; ; thymus; ; mesenteric lymph nodes; ; umbilical cord; ; tibiofemoral joint; ; dorsal striatum; ; choroid plexus of fourth ventricle; ; sexually immature organism;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	calcium ion binding; enzyme inhibitor activity; transporter activity; cysteine-type endopeptidase inhibitor activity;
Cellular component	extracellular region; extracellular space;
Biological process	negative regulation of lactation; lactation; calcium ion transport; negative regulation of cysteine-type endopeptidase activity; transport;
	Sources:Amigo / QuickGO
Orthologs
Databases	NCBI: entry; OMA: entry
	1447
	12991
	ENSG00000135222; ENSG00000283030
	ENSMUSG00000063157
	P05814
	P10598
	NM_001302770; NM_001891; NM_001385731
NM_001286020; NM_001286021; NM_001286022; NM_001286023; NM_001286024;
	NM_009972
	NP_001289699; NP_001882
NP_001272949; NP_001272950; NP_001272951; NP_001272952; NP_001272953;
	NP_034102
	Wikidata
View/Edit Human	View/Edit Mouse

Beta-casein is a protein that in humans is encoded by the CSN2 gene.^[5]^[6] It is in the class of phosphoproteins and generally occurs in mammalian milk.

References

1 2 3 ENSG00000283030 GRCh38: Ensembl release 89: ENSG00000135222, ENSG00000283030 – Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000063157 – Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ Menon RS, Chang YF, Jeffers KF, Jones C, Ham RG (Jun 1992). "Regional localization of human beta-casein gene (CSN2) to 4pter-q21". Genomics. 13 (1): 225–6. doi:10.1016/0888-7543(92)90227-J. PMID 1577486.
↑ "Entrez Gene: CSN2 casein beta".

External links

Human CSN2 genome location and CSN2 gene details page in the UCSC Genome Browser.

Letwin K, Mizzen L, Motro B, et al. (1992). "A mammalian dual specificity protein kinase, Nek1, is related to the NIMA cell cycle regulator and highly expressed in meiotic germ cells". EMBO J. 11 (10): 3521–31. doi:10.1002/j.1460-2075.1992.tb05435.x. PMC 556810. PMID 1382974.
Lönnerdal B, Bergström S, Andersson Y, et al. (1990). "Cloning and sequencing of a cDNA encoding human milk beta-casein". FEBS Lett. 269 (1): 153–6. doi:10.1016/0014-5793(90)81142-B. PMID 2387396. S2CID 84999340.
Menon RS, Ham RG (1989). "Human beta-casein: partial cDNA sequence and apparent polymorphism". Nucleic Acids Res. 17 (7): 2869. doi:10.1093/nar/17.7.2869. PMC 317677. PMID 2717418.
Greenberg R, Groves ML, Dower HJ (1984). "Human beta-casein. Amino acid sequence and identification of phosphorylation sites". J. Biol. Chem. 259 (8): 5132–8. doi:10.1016/S0021-9258(17)42966-8. PMID 6715339.
Chen CS, Bejcek BE, Kersey JH (1995). "A mapping study of 13 genes on human chromosome bands 4q11→q25". Cytogenet. Cell Genet. 69 (3–4): 260–5. doi:10.1159/000133976. PMID 7698025.
Hansson L, Edlund A, Johansson T, et al. (1994). "Structure of the human beta-casein encoding gene". Gene. 139 (2): 193–9. doi:10.1016/0378-1119(94)90754-4. PMID 8112603.
McConkey EH, Menon R, Williams G, et al. (1996). "Assignment of the gene for beta-casein (CSN2) to 4q13 → q21 in humans and 3p13 → p12 in chimpanzees". Cytogenet. Cell Genet. 72 (1): 60–2. doi:10.1159/000134163. PMID 8565637.
Wilmouth RC, Clifton IJ, Robinson CV, et al. (1997). "Structure of a specific acyl-enzyme complex formed between beta-casomorphin-7 and porcine pancreatic elastase". Nat. Struct. Biol. 4 (6): 456–62. doi:10.1038/nsb0697-456. PMID 9187653. S2CID 46268643.
Winklehner-Jennewein P, Geymayer S, Lechner J, et al. (1998). "A distal enhancer region in the human beta-casein gene mediates the response to prolactin and glucocorticoid hormones". Gene. 217 (1–2): 127–39. doi:10.1016/S0378-1119(98)00380-1. PMID 9795185.
Gray CW, Ward RV, Karran E, et al. (2000). "Characterization of human HtrA2, a novel serine protease involved in the mammalian cellular stress response". Eur. J. Biochem. 267 (18): 5699–710. doi:10.1046/j.1432-1327.2000.01589.x. PMID 10971580.
Sood SM, Slatter CW (2003). "Suspension of the calcium-sensitive human beta-caseins by human kappa-casein". J. Dairy Sci. 85 (6): 1353–6. doi:10.3168/jds.S0022-0302(02)74200-8. PMID 12146463.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Ohashi A, Murata E, Yamamoto K, et al. (2003). "New functions of lactoferrin and beta-casein in mammalian milk as cysteine protease inhibitors". Biochem. Biophys. Res. Commun. 306 (1): 98–103. doi:10.1016/S0006-291X(03)00917-3. PMID 12788072.
Reimer T, Weiwad M, Schierhorn A, et al. (2003). "Phosphorylation of the N-terminal domain regulates subcellular localization and DNA binding properties of the peptidyl-prolyl cis/trans isomerase hPar14". J. Mol. Biol. 330 (5): 955–66. doi:10.1016/S0022-2836(03)00713-7. PMID 12860119.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Miller SL, DeMaria JE, Freier DO, et al. (2005). "Novel association of Vav2 and Nek3 modulates signaling through the human prolactin receptor". Mol. Endocrinol. 19 (4): 939–49. doi:10.1210/me.2004-0443. PMID 15618286.
Sood SM, Lekic T, Jhawar H, et al. (2007). "Reconstituted micelle formation using reduced, carboxymethylated bovine kappa-casein and human beta-casein". Protein J. 25 (5): 352–60. doi:10.1007/s10930-006-9022-7. PMID 16947075. S2CID 84941322.
Buser AC, Gass-Handel EK, Wyszomierski SL, et al. (2007). "Progesterone receptor repression of prolactin/signal transducer and activator of transcription 5-mediated transcription of the beta-casein gene in mammary epithelial cells". Mol. Endocrinol. 21 (1): 106–25. doi:10.1210/me.2006-0297. PMID 16973758.

This article on a gene on human chromosome 4 is a stub. You can help Wikipedia by adding missing information.

[refGRCh38Ensembl-1] 1 2 3 ENSG00000283030 GRCh38: Ensembl release 89: ENSG00000135222, ENSG00000283030 – Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000063157 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid1577486-5] Menon RS, Chang YF, Jeffers KF, Jones C, Ham RG (Jun 1992). "Regional localization of human beta-casein gene (CSN2) to 4pter-q21". Genomics. 13 (1): 225–6. doi:10.1016/0888-7543(92)90227-J. PMID 1577486.

[entrez-6] "Entrez Gene: CSN2 casein beta".

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// Workers AI · dad joke modeWhat did CSN2 say to its date? "You're a formula for love, CSN2 me".

See also

References

External links

Further reading