ATPase ASNA1

GET3
Identifiers
Aliases	GET3, ARSA-I, ARSA1, ASNA-I, TRC40, hASNA-I, arsA arsenite transporter, ATP-binding, homolog 1 (bacterial), ASNA1, Guided Entry Of Tail-Anchored Proteins Factor 3, ATPase
External IDs	OMIM: 601913; MGI: 1928379; GeneCards: GET3
Gene location (Human) Chr. Chromosome 19 (human) Band 19p13.13 Start 12,737,139 bp End 12,748,323 bp
Gene location (Mouse) Chr. Chromosome 8 (mouse) Band 8|8 C3 Start 85,744,560 bp End 85,751,910 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in monocyte stromal cell of endometrium prefrontal cortex right adrenal gland apex of heart right adrenal cortex right frontal lobe left adrenal gland right testis islet of Langerhans Top expressed in choroid plexus of fourth ventricle yolk sac epiblast dentate gyrus of hippocampal formation granule cell neural layer of retina superior frontal gyrus primary visual cortex central gray substance of midbrain perirhinal cortex medulla oblongata More reference expression data BioGPS More reference expression data
Gene ontology Molecular function nucleotide binding ATPase activity protein binding hydrolase activity ATP binding arsenite transmembrane transporter activity metal ion binding transporter activity ATPase-coupled transmembrane transporter activity Cellular component cytoplasm nucleolus extracellular exosome endoplasmic reticulum membrane nucleus endoplasmic reticulum GET complex Biological process IRE1-mediated unfolded protein response inorganic anion transport transport posttranslational protein targeting to endoplasmic reticulum membrane arsenite transport protein insertion into ER membrane tail-anchored membrane protein insertion into ER membrane Sources:Amigo / QuickGO
Orthologs Databases NCBI: entry; OMA: entry Species Human Mouse Entrez 439 56495 Ensembl ENSG00000198356 ENSMUSG00000052456 UniProt O43681 O54984 RefSeq (mRNA) NM_004317 NM_019652 NM_001357202 NM_001357203 RefSeq (protein) NP_004308 NP_001358417 NP_001358418 NP_062626 NP_001344131 NP_001344132 Location (UCSC) Chr 19: 12.74 – 12.75 Mb Chr 8: 85.74 – 85.75 Mb PubMed search
Wikidata
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ATPase GET3 (also known as ATPase ASNA1, arsenical pump-driving ATPase and arsenite-stimulated ATPase) is an enzyme that in humans is encoded by the gene GET3 (previously ASNA1).

Function

GET3 is the human homolog of the bacterial arsA gene. In E. coli, arsA ATPase is the catalytic component of a multisubunit oxyanion pump that is responsible for resistance to arsenicals and antimonials.

Interactions

The protein GET3 is found to interact with FAM71D according to STRING

External links

• Human ASNA1 genome location and ASNA1 gene details page in the UCSC Genome Browser.

Further reading

• Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
• Kurdi-Haidar B, Heath D, Aebi S, Howell SB (1998). "Biochemical characterization of the human arsenite-stimulated ATPase (hASNA-I)". J. Biol. Chem. 273 (35): 22173–6. doi:10.1074/jbc.273.35.22173. PMID 9712828.
• Kurdi-Haidar B, Hom DK, Flittner DE, et al. (1998). "Dual cytoplasmic and nuclear distribution of the novel arsenite-stimulated human ATPase (hASNA-I)". J. Cell. Biochem. 71 (1): 1–10. doi:10.1002/(SICI)1097-4644(19981001)71:1<1::AID-JCB1>3.0.CO;2-#. PMID 9736449. S2CID 196597195.
• Kurdi-Haidar B, Heath D, Lennon G, Howell SB (2000). "Chromosomal localization and genomic structure of the human arsenite-stimulated ATPase (hASNA-I)". Somat. Cell Mol. Genet. 24 (5): 307–11. doi:10.1023/B:SCAM.0000007134.16744.8b. PMID 10696239. S2CID 11936516.
• Kao G, Nordenson C, Still M, et al. (2007). "ASNA-1 positively regulates insulin secretion in C. elegans and mammalian cells". Cell. 128 (3): 577–87. doi:10.1016/j.cell.2006.12.031. PMID 17289575. S2CID 2120123.
• Stefanovic S, Hegde RS (2007). "Identification of a targeting factor for posttranslational membrane protein insertion into the ER". Cell. 128 (6): 1147–59. doi:10.1016/j.cell.2007.01.036. PMID 17382883. S2CID 16802797.