Mitogen-activated protein kinase kinase kinase 6

MAP3K6
Identifiers
Aliases	MAP3K6, ASK2, MAPKKK6, MEKK6, mitogen-activated protein kinase kinase kinase 6
External IDs	OMIM: 604468; MGI: 1855691; HomoloGene: 3435; GeneCards: MAP3K6; OMA:MAP3K6 - orthologs
Enzyme activity EC # BRENDA ExPASy KEGG MetaCyc 2.7.11.25 ↗ ↗ ↗ ↗
Gene location (Human) Chr. Chromosome 1 (human) Band 1p36.11 Start 27,354,067 bp End 27,366,961 bp
Gene location (Mouse) Chr. Chromosome 4 (mouse) Band 4|4 D2.3 Start 132,968,129 bp End 132,980,240 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in right lung skin of abdomen skin of leg apex of heart ectocervix upper lobe of left lung left uterine tube tibial nerve canal of the cervix gastric mucosa Top expressed in primary oocyte zygote secondary oocyte superior surface of tongue corneal stroma hair follicle lip umbilical cord muscle of thigh esophagus More reference expression data BioGPS n/a
Gene ontology Molecular function transferase activity nucleotide binding protein kinase activity protein serine/threonine kinase activity MAP kinase kinase kinase activity ATP binding magnesium ion binding metal ion binding kinase activity Cellular component intracellular anatomical structure Biological process protein phosphorylation phosphorylation signal transduction Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 9064 53608 Ensembl ENSG00000142733 ENSMUSG00000028862 UniProt O95382 Q9WTR2 RefSeq (mRNA) NM_001297609 NM_004672 NM_145319 NM_016693 RefSeq (protein) NP_001284538 NP_004663 NP_057902 Location (UCSC) Chr 1: 27.35 – 27.37 Mb Chr 4: 132.97 – 132.98 Mb PubMed search
Wikidata
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Mitogen-activated protein kinase kinase kinase 6 is a protein that in humans is encoded by the MAP3K6 gene.

Function

This gene encodes a serine/threonine protein kinase that forms a component of protein kinase-mediated signal transduction cascades. The encoded kinase participates in the regulation of vascular endothelial growth factor (VEGF) expression. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2014].

Further reading

• Takeda K, Shimozono R, Noguchi T, Umeda T, Morimoto Y, Naguro I, Tobiume K, Saitoh M, Matsuzawa A, Ichijo H (March 2007). "Apoptosis signal-regulating kinase (ASK) 2 functions as a mitogen-activated protein kinase kinase kinase in a heteromeric complex with ASK1". J. Biol. Chem. 282 (10): 7522–31. doi:10.1074/jbc.M607177200. PMID 17210579.
• Arning L, Monté D, Hansen W, Wieczorek S, Jagiello P, Akkad DA, Andrich J, Kraus PH, Saft C, Epplen JT (April 2008). "ASK1 and MAP2K6 as modifiers of age at onset in Huntington's disease". J. Mol. Med. 86 (4): 485–90. doi:10.1007/s00109-007-0299-6. PMID 18327563. S2CID 9535075.
• Eto N, Miyagishi M, Inagi R, Fujita T, Nangaku M (April 2009). "Mitogen-activated protein 3 kinase 6 mediates angiogenic and tumorigenic effects via vascular endothelial growth factor expression". Am. J. Pathol. 174 (4): 1553–63. doi:10.2353/ajpath.2009.080190. PMC 2671385. PMID 19246638.
• Talmud PJ, Drenos F, Shah S, Shah T, Palmen J, Verzilli C, Gaunt TR, Pallas J, Lovering R, Li K, Casas JP, Sofat R, Kumari M, Rodriguez S, Johnson T, Newhouse SJ, Dominiczak A, Samani NJ, Caulfield M, Sever P, Stanton A, Shields DC, Padmanabhan S, Melander O, Hastie C, Delles C, Ebrahim S, Marmot MG, Smith GD, Lawlor DA, Munroe PB, Day IN, Kivimaki M, Whittaker J, Humphries SE, Hingorani AD (November 2009). "Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip". Am. J. Hum. Genet. 85 (5): 628–42. doi:10.1016/j.ajhg.2009.10.014. PMC 2775832. PMID 19913121.
• Bailey SD, Xie C, Do R, Montpetit A, Diaz R, Mohan V, Keavney B, Yusuf S, Gerstein HC, Engert JC, Anand S (October 2010). "Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study". Diabetes Care. 33 (10): 2250–3. doi:10.2337/dc10-0452. PMC 2945168. PMID 20628086.
• Gaston D, Hansford S, Oliveira C, Nightingale M, Pinheiro H, Macgillivray C, Kaurah P, Rideout AL, Steele P, Soares G, Huang WY, Whitehouse S, Blowers S, LeBlanc MA, Jiang H, Greer W, Samuels ME, Orr A, Fernandez CV, Majewski J, Ludman M, Dyack S, Penney LS, McMaster CR, Huntsman D, Bedard K (October 2014). "Germline mutations in MAP3K6 are associated with familial gastric cancer". PLOS Genet. 10 (10) e1004669. doi:10.1371/journal.pgen.1004669. PMC 4207611. PMID 25340522.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.