Apolipoprotein L3

APOL3
Identifiers
Aliases	APOL3, APOLIII, CG121, CG12_1, apoL-III, apolipoprotein L3
External IDs	OMIM: 607253; GeneCards: APOL3
Gene location (Human) Chr. Chromosome 22 (human) Band 22q12.3 Start 36,140,330 bp End 36,166,177 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in granulocyte monocyte apex of heart gastric mucosa pericardium lymph node spleen subcutaneous adipose tissue right lung tendon of biceps brachii n/a More reference expression data BioGPS More reference expression data
Gene ontology Molecular function signal transducer activity lipid binding lipid transporter activity Cellular component cytoplasm extracellular region membrane Biological process lipoprotein metabolic process positive regulation of I-kappaB kinase/NF-kappaB signaling lipid transport inflammatory response signal transduction transport Sources:Amigo / QuickGO
Orthologs Databases NCBI: entry; OMA: entry Species Human Mouse Entrez 80833 n/a Ensembl ENSG00000128284 n/a UniProt O95236 n/a RefSeq (mRNA) NM_014349 NM_030644 NM_145639 NM_145640 NM_145641 NM_145642 n/a RefSeq (protein) NP_055164 NP_085147 NP_663614 NP_663615 NP_663616 NP_663617 n/a Location (UCSC) Chr 22: 36.14 – 36.17 Mb n/a PubMed search n/a
Wikidata
View/Edit Human

Apolipoprotein L3 is a protein that in humans is encoded by the APOL3 gene. Expressed in the gut, it has antibiotic properties.

This gene is a member of the apolipoprotein L gene family. The encoded protein is found in the cytoplasm, where it may affect the movement of lipids or allow the binding of lipids to organelles. In addition, expression of this gene is upregulated by tumor necrosis factor-alpha in endothelial cells lining the normal and atherosclerotic iliac artery and aorta. Six transcript variants encoding three different isoforms have been found for this gene.

External links

• Human APOL3 genome location and APOL3 gene details page in the UCSC Genome Browser.

Further reading

• Horrevoets AJ, Fontijn RD, van Zonneveld AJ, de Vries CJ, ten Cate JW, Pannekoek H (May 1999). "Vascular endothelial genes that are responsive to tumor necrosis factor-alpha in vitro are expressed in atherosclerotic lesions, including inhibitor of apoptosis protein-1, stannin, and two novel genes". Blood. 93 (10): 3418–31. doi:10.1182/blood.V93.10.3418.410k23_3418_3431. PMID 10233894.
• Dunham I, Shimizu N, Roe BA, Chissoe S, Hunt AR, Collins JE, et al. (December 1999). "The DNA sequence of human chromosome 22". Nature. 402 (6761): 489–95. Bibcode:1999Natur.402..489D. doi:10.1038/990031. PMID 10591208.
• Duchateau PN, Pullinger CR, Cho MH, Eng C, Kane JP (April 2001). "Apolipoprotein L gene family: tissue-specific expression, splicing, promoter regions; discovery of a new gene". Journal of Lipid Research. 42 (4): 620–30. doi:10.1016/S0022-2275(20)31171-8. PMID 11290834.
• Monajemi H, Fontijn RD, Pannekoek H, Horrevoets AJ (April 2002). "The apolipoprotein L gene cluster has emerged recently in evolution and is expressed in human vascular tissue". Genomics. 79 (4): 539–46. doi:10.1006/geno.2002.6729. PMID 11944986.
• Matsuda A, Suzuki Y, Honda G, Muramatsu S, Matsuzaki O, Nagano Y, et al. (May 2003). "Large-scale identification and characterization of human genes that activate NF-kappaB and MAPK signaling pathways". Oncogene. 22 (21): 3307–18. doi:10.1038/sj.onc.1206406. PMID 12761501.
• Collins JE, Wright CL, Edwards CA, Davis MP, Grinham JA, Cole CG, et al. (2005). "A genome annotation-driven approach to cloning the human ORFeome". Genome Biology. 5 (10): R84. doi:10.1186/gb-2004-5-10-r84. PMC 545604. PMID 15461802.
• Ma J, Dempsey AA, Stamatiou D, Marshall KW, Liew CC (March 2007). "Identifying leukocyte gene expression patterns associated with plasma lipid levels in human subjects". Atherosclerosis. 191 (1): 63–72. doi:10.1016/j.atherosclerosis.2006.05.032. PMID 16806233.